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What does the Hyaluronidase do?

We use hyaluronidase in the treatment of overcorrection or misplacement of Hyaluronic Acid dermal fillers. Hyaluronidase are a family of enzymes that can degrade injected cross-linked hyaluronic acid HA dermal fillers.
They have also been employed for many years in medicine to increase drug diffusion. They are useful for dissolving subcutaneous nodules and for reversing excessive quantities of injected filler. However, a thorough knowledge of their methods of use and their own adverse effects is essential for the oculoplastic surgeon.
I recommend an excellent review in anaesthetic surgery journal by Maurizio Cavallini published in November 2013, pages 1167 to 1174, in which they look at all the papers they could find about Hyaluronidase between 1928 and 2011. You will find this anaesthetic surgery journal by clicking here.
They found that not only is the Hyaluronidase used in anaesthetic medicine to prevent complications from an inappropriate injection of HA, to eliminate HA nodules, or correct unsightly HA over filling, but also that enzymes had been used for many years as a spreading agent to promote diffusion of substances injected subcutaneously. It has also been used in ophthalmology and cataract surgery as early as the 1970s and 80s. The Hyaluronidase acts on Hyaluronic acid which is a glycosaminoglycan, GAG.


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