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What is hyaluronidase?

Many patients who have hyaluronic acid gel are very happy with their treatment. However, there are some patients, a lot of time from other practitioners, who are not happy with their treatment. This can be either that the wrong gel has been used or it’s been put into the wrong place or done with the wrong technique.
So we have a lot of patients that come here to Clinica London asking me to reverse their restylane or their juvederm, their hyaluronic acid gel. This is possible using an enzyme called hyaloronidase. However, this enzyme has to be injected and the treatment is only on prescription.
So if patients have a problem with their filler, they come and see myself and the nurse for an assessment and we discuss how long ago they’ve had the filler, what the problem is with it (it can be lumpy, it could have shifted, moved or it can be a very heavy filler they don’t like). Then we talk to them about hyaluronidase: what it is, how it works.
Now, everybody’s made up of hyaluronic acid gel, large proportion of our body and we also have natural hyaluronidase. The difference is with the hyaluronic acid gel that it is syntactically injected as a filler, is cross-linked. This is a little bit technical, but the cross-linking means that it only gets taken away by your body very slowly. That’s why we have to inject hyaluronidase enzyme.
One question I’m often asked is if this enzyme affects the normal soft tissue? There’s absolutely no evidence that I or other practitioners could find that using hyaluronidase enzyme of licence to reverse fillers could also affect your own tissue.
It’s a very effective injection for reversing hyaluronic acid gel. It’s done under local anaesthetic and it works immediately. There are potential side effects. This is discomfort of the injection, possibly little bit of bruising and swelling and very small risk of allergy, particularly if you’ve had it done before.
That’s why it is important to come and have a proper consultation and discuss the merits and problems, or deficits of considering hyaluronidase to reverse your filler, because there’s still the option just to gradually let it go away.

More about Jane Olver

Ms Jane Olver is the founder of Clinica London and a Consultant Ophthalmologist and Oculoplastic Surgeon. Her special expertise is in oculoplastic and cosmetic eye surgery including eyelids and lacrimal surgery. She is specialised in endoscopic lacrimal surgery for watering eyes in adults and children. She has over 20 years’ experience in treating people with eye problems just like you, and has published extensively in scientific journals about Ophthalmology and Lacrimal Surgery and is the author of the books “Ophthalmology at a Glance” and “Colour Atlas of Lacrimal Surgery”. At Clinica London, she is responsible for the Aesthetic Medicine and Surgery part, as well as patients with eye, eyelid and tear duct problems, and acute eye problems.


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